目的 优化乳牙根管充填用碘仿糊的处方。方法 以糊剂的细腻程度、润滑性、根管充填难易程度、去除难易程度等作为考察指标，采用多指标综合评分法对基质种类进行筛选，采用正交试验设计法对处方比例进行优化;并采用紫外分光光度法对优化处方中碘仿进行含量测定。结果 多指标综合评分法选择二甲基硅油作为糊剂基质。正交试验结果显示，碘仿/氧化锌比例为影响糊剂的主要因素，确定优化处方为:碘仿/氧化锌比例为3∶7、丁香油比例为1.5%、粉/液比例为70∶30。优化处方中碘仿测定的线性方程为A=6.781 3C-0.051 6(r=0.999 7)，表明碘仿浓度在48.75~146.26 μg·mL-1内与吸收度呈良好的线性关系，平均回收率为99.83%(n=9)。结论 优化后的碘仿糊剂制备工艺简单，外观均匀细腻，润滑性好，便于进行乳牙根管充填。建立的碘仿含量测定方法准确、可靠，制剂质量可控。
Abstract
OBJECTIVE To optimize the formulation of iodoform paste for root canal filling of deciduous teeth. METHODS Using multi-indicators comprehensive scoring method, which takes the delicate degree, lubricity, difficulty of root canal filling, and difficulty of removal as performance indicators, the matrix type was screened, and the formulation of paste was optimized by orthogonal experimental design. The content of iodoform in the optimized paste was determined by UV spectrophotometry. RESULTS Dimethicone was chosen as the paste matrix by comprehensive scoring of indicators. The results of orthogonal test showed that the ratio of iodoform and zinc oxide was the main factor affecting the performance of the paste, and the optimal formulation of paste was as follows:the ratio of iodoformto zinc oxide 3∶7, clove oil 0.5%, and the ratio of powder to liquid 70∶30. The linear range of the calibration curve for iodoform in the optimal paste was 48.75-146.22 μg·mL-1, A=6.781 3C-0.051 6(r=0.999 6); and the average recovery rate was 99.83% (n=9). CONCLUSION The optimal iodoform paste has a simple preparation, fine and smooth for root canal filling of deciduous teeth. The assay method is accurate and reliable for the quality control of iodoform paste.
关键词
碘仿糊剂 /
乳牙 /
根管充填 /
处方优化 /
正交试验 /
含量测定
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Key words
iodoform paste /
deciduous teeth /
root canal filling /
formulation optimization /
orthogonal test /
determination
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中图分类号：
R944
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